Protein a-klotho
WebbThe Klotho protein, also known as α-Klotho, is a multifunctional protein that regulates the metabolism of phosphate, calcium, and vitamin D. Klotho may also function as a hormone. Three Klotho protein types with potentially different functions have been identified: a full-length transmembrane Klotho, a truncated soluble Klotho, and a secreted Klotho. Webb19 nov. 2024 · The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine fibroblast growth factor (FGF) receptor complexes, as they are required for …
Protein a-klotho
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WebbTwo forms of alpha-Klotho protein have been reported: a membrane-bound and a soluble one. Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors … Webb2 feb. 2024 · Klotho is an anti-aging protein that is mostly secrete by the kidneys, the brain, and the thyroid. R. It plays a major role in regulating kidney function and vascular health. R. The name for the klotho gene …
WebbKlotho acts as a cofactor for interaction of FGF23 with FGF R1 (6). This interaction negatively regulates 1 alpha -hydroxylase, the rate-limiting enzyme in the synthesis of 1,25 (OH) 2 D 3 (vitamin D) (7). Klotho-deficient mice show severe hyperphosphatemia and ectopic calcification of soft tissues due to excess vitamin D (2, 7). Webb11 juni 2024 · Klotho is a natural protein enzyme that exists within the body and brain. This protein is created by the KL gene and is produced in the kidneys. It appears to have …
The klotho protein is a novel β-glucuronidase (EC number 3.2.1.31) capable of hydrolyzing steroid β-glucuronides. Genetic variants in KLOTHO have been associated with human aging, [18] [19] and klotho protein has been shown to be a circulating factor detectable in serum that declines with age. Visa mer Klotho is an enzyme that in humans is encoded by the KL gene. The three subfamilies of klotho are α-klotho, β-klotho, and γ-klotho. α-klotho activates FGF23, and β-klotho activates FGF19 and FGF21. … Visa mer The α-klotho gene is located on chromosome 13, and is translated into a single-pass integral membrane protein. The intracellular portion of the α-klotho protein is short (11 amino acids), whereas the extracellular portion is long (980 amino acids). The … Visa mer Reduced α-klotho or FGF23 can result in impaired phosphate excretion from the kidney, leading to hyperphosphatemia. In mice, this leads to a phenotype characteristic of … Visa mer • Biology portal • "KL klotho [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-03-20. Visa mer Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to Visa mer α-klotho can suppress oxidative stress and inflammation, thereby reducing endothelial dysfunction and atherosclerosis. Blood plasma α-klotho is … Visa mer • Shimoyama Y, Taki K, Mitsuda Y, Tsuruta Y, Hamajima N, Niwa T (2009). "KLOTHO gene polymorphisms G-395A and C1818T are associated with low-density lipoprotein cholesterol and uric … Visa mer
WebbThe Klotho protein, also known as α-Klotho, is a multifunctional protein that regulates the metabolism of phosphate, calcium, and vitamin D. Klotho may also function as a …
Webb24 dec. 2024 · Klotho is a membrane-bound or soluble antiaging protein, whose protective activity is essential for a proper function of many organs. In 1997, an accidental insertion of a transgene led to creation of transgenic mice with several age-related disorders. In Klotho-deficient mice, the inherited phenotypes closely resemble human aging, while in an … the way you look lyrics sinatraWebb17 juni 2014 · Klotho is a powerful longevity protein that has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular disease. Similar anti-aging effects … the way you look tonight chords guitarWebb29 nov. 2024 · A protein is one or more polypeptides, long chains of amino acids held together by peptide bonds. Proteins are vital for structure, growth and repair in the body, … the way you look tonight buble lyricsWebbKlotho, an antiaging protein closely related to arteriosclerosis, is mainly expressed in the kidney, 3 and its expression decreases with age. 4 Klotho proteins are divided into membrane-bound, soluble and secreted forms, and circulating Klotho includes soluble and secreted forms. 5 Studies have shown that the expression of circulating blood Klotho is … the way you look lyricsWebbKlotho est une protéine transmembranaire qui, parallèlement à d'autres fonctions, permet un certain contrôle de la sensibilité de l'organisme à l' insuline et semble être impliquée dans le vieillissement. La protéine Klotho est associée aux bêta -Glucuronidase (EC 3.2.1.31) et est capable d'hydrolyser les stéroïdes β-glucuronides. the way you look tonight coverWebb22 mars 2024 · Heart disease is the leading cause of death worldwide. The major cause of heart failure is the death of the myocardium caused by myocardial infarction, detrimental … the way you look tonight country songWebb1 juni 2003 · 8.A.49.1.2 the klotho auxiliary protein (klotho) family Names & Taxonomy Protein names Recommended name Beta-klotho Short names BKL; BetaKlotho Alternative names Klotho beta-like protein Gene names Name KLB Organism names Organism Homo sapiens (Human) Taxonomic identifier 9606 NCBI Taxonomic lineage the way you look tonight chords lyrics