Macrophage migration inhibitory factor (MIF), also known as glycosylation-inhibiting factor (GIF), L-dopachrome isomerase, or phenylpyruvate tautomerase is a protein that in humans is encoded by the MIF gene. MIF is an important regulator of innate immunity. The MIF protein superfamily also includes a … Meer weergeven Macrophage migration inhibitory factor assembles into a trimer composed of three identical subunits. Each of these monomers contain two antiparallel alpha helices and a four-stranded beta sheet. The monomers … Meer weergeven Cytokines play an important role in promoting wound healing and tissue repair. Cell injury results in MIF release which then interacts with CD74. MIF-CD74 signaling activates pro-survival and proliferative pathways that protects the host during … Meer weergeven MIF binds to CD74, inducing its phosphorylation and the recruitment of CD44 which then activates non-receptor tyrosine kinases, leading ultimately to Meer weergeven MIF is a potential drug target for sepsis, rheumatoid arthritis, and cancer. Meer weergeven MIF contains two motifs with catalytic activity. The first is a 27 amino acid motif located at the N-terminus functions as a Meer weergeven This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. MIF plays a role … Meer weergeven Macrophage migration inhibitory factor has been reported to interact with: • BNIPL, • CD74, • COPS5, • CXCR4, and • RPS19. Meer weergeven WebMIF has a chemokine-like function that activates CXCR2 and CXCR4, and thus can recruit monocytes and T lymphocytes to promote atherosclerosis (57,59, 60). ...
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WebA novel link between the chemokine MIF and B lymphocytes in atherosclerosis. Mar 2024 – The Bernhagen lab uncovered a previously unrecognized connection between the … Web24 okt. 2024 · Chemokine-Like Functions of MIF in Inflammatory Cell Recruitment. The superfamily of chemokines governs leukocyte trafficking and deployment during … graphic tee trends
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WebRole of MIF in coordinated expression of hepatic chemokines in patients with alcohol-associated hepatitis. This study demonstrates that patients with AH exhibit a specific, … Web28 mei 2014 · In the CNS, the chemokine CXCL12 promotes remyelination via CXCR4 activation on OPCs, ... Macrophage migration inhibitory factor (MIF) ... Web21 mrt. 2024 · The autocrine/paracrine macrophage migration inhibitory factor (MIF)/chemokines CXCR4/CXCR7 axis plays an important pleiotropic role in … chiropractorwakeforest.com