WebbIACS-8803 shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma ... Zhang H, Wei Z, Jones P, Curran MA, Di Francesco ME. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg ... Webb26 jan. 2024 · iacs-8968 是 ido 和 tdo 的双抑制剂，其 pic50s 值分别为 6.43， 5。 相关类别 信号通路 >> 代谢酶/蛋白酶 >> 吲哚胺2,3-二氧化酶(IDO)

Discovery of IACS-8803 and IACS-8779, potent agonists of …

Webb24 aug. 2024 · Treatment with ‘8779 and ‘8803 also resulted in a higher number of mice cured of both tumors compared to benchmarks (Figure 4b). Follow up studies in additional tumor models and dose down experiments are planned with IACS-8779 and IACS-8803, and will be reported in a forthcoming article. 20 WebbIACS-8779 Cat. No.: HY-130116 IACS-8779 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy. Purity: >98% Clinical Data:No Development Reported Size: 1 mg, 5 mg IACS-8779 disodium Cat. No.: HY-130116A IACS-8779 disodium is a highly potent stimulator of interferon genes (STING) … red river cereal recall

Stimulator of Interferon Genes MedChemExpress Life Science …

Webb4 sep. 2024 · IACS-8779 (C 21 H 25 N 9 O 10 P 2 S 2) and IACS-8803 (C 20 H 23 FN 10 O 9 P 2 S 2) are both STING agonists with robust systemic antitumor efficacy. Mice … WebbWe report the discovery of two highly potent cyclic dinucleotide STING agonists, IACS-8803 and IACS-8779, which show robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma when compared to one of the clinical benchmark compounds.", keywords = "Cyclic … Webb2 feb. 2024 · iacs-8779二钠是一种高效的干扰素基因刺激剂（sting）激动剂，具有强大的全身抗肿瘤功效。 IACS-8779二钠在体外显示出STING通路的强烈激活，在B16小鼠黑 … red river cereal usa