Cisplatin mouse

WebCisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use.... WebSep 1, 2024 · First, we examined whether cisplatin altered renal iron levels and induced oxidative stress in mice. Cisplatin increased the production of ferrous iron and hydroxyl radical, and they were colocalized in the kidney, suggesting the occurrence of the Fenton reaction ( Fig. 1 A–C).

Cisplatin nephrotoxicity as a model of chronic kidney disease

WebApr 14, 2024 · The investigations demonstrated different impacts of cisplatin on CTR1 expression on the single-cell level according to the resistance status. The study showed this interrelation for the first time at the single-cell level. It could be shown in this study that the resistant ovarian cancer cells as compared to the sensitive cells are ... WebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... Thus, … how is performance measured in scrum https://rubenesquevogue.com

Cisplatin dosing, indications, interactions, adverse effects

WebJan 18, 2024 · Cisplatin-induced DNA damage maps across mouse organs. Here, we adopted a previously developed high-throughput sequencing protocol, Damage-seq 15, for assaying genome-wide DNA damage with single ... WebMar 16, 2024 · Cisplatin is an alkylating-like platinum-based chemotherapeutic drug commonly used in paediatric oncology [ 5 ]. The understanding of how exposure to cisplatin affects the future fertility of pre-pubertal boys predominantly comes from retrospective follow-up studies [ 6 ]. how is performance profiling used in football

Developing better mouse models to study cisplatin …

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Cisplatin mouse

Cisplatin Mouse Models: Treatment, Toxicity and …

WebFeb 18, 2024 · C57BL/6 mice were intraperitoneally injected with cisplatin (15 mg/kg) and then sacrificed at 8, 12, 24, and 72 h. A The body weight decreased 8–72 h after cisplatin treatment ( n = 4). B... WebSep 1, 2024 · Cisplatin for injection can cause severe hypersensitivity reactions, including anaphylaxis and death. Manifestations have included facial edema, wheezing, …

Cisplatin mouse

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WebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has been reported, the role of phosphate in the cisplatin-induced CKD progression is not described. WebAug 28, 2024 · Three specific models using paclitaxel or cisplatin that stand out are 1) C57BL/6 female mice receiving paclitaxel and 2) CD1 male mice receiving paclitaxel and 3) C57BL/6 male mice receiving cisplatin. This overview may help scientists selecting suitable CIPN models for their research.

WebDec 24, 2024 · In this approach, cisplatin treatment was started when primary tumors were palpable (200–300 mm 3 ). When primary tumors bearing legs reached 15–17 mm (Day 35), three mice from control and... Webstudies in mice and rats, cisplatin acted as a tumor initiator follow-ing transplacental exposure via a single intraperitoneal injection late in gestation. In mice, transplacental …

WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney … WebMay 11, 2012 · Mice were given LPs-pVAX or LPs-pVAX-LKB1 complexes by intratumoral injection at a dose of 20 μg per mice and/or low-dose cisplatin (2 mg kg −1 per mice) by i.p injection. After 24 h of the ...

WebDec 12, 2024 · Cisplatin is one of the most generally used and highly effective chemotherapy drugs for the treatment of various types of human cancer, such as testicular, ovarian, head and neck, bladder, bone,...

WebDec 2, 2024 · Cisplatin is a commonly used chemotherapeutic drug for cancer treatment, but its nephrotoxicity may lead to the deterioration of renal function. Previous work has been focused on cisplatin-induced acute … how is performing at the super bowl 2021WebAug 17, 2024 · Cisplatin (cis-Diaminodichloroplatinum, CDDP), one of the most potent chemotherapeutic agents, has been proven effective against various solid tumors, including sarcoma, soft tissue cancer, bone cancer, muscle cancer, and vascular cancer. how is performing at the super bowl 2023WebWe recently reported that human and mouse cells containing an African-specific coding region variant of p53, Pro47Ser (hereafter S47), are impaired in the transactivation of a small subset of p53 ... how is perianal strep transmittedWebCisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles The backbone of ovarian cancer treatment is platinum-based chemotherapy and aggressive surgical debulking. how is perforomist dispensedWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … how is perfume made step by stepWebSep 2, 2024 · Animals and Experimental Models. C57BL/6 mice (male, aged 8 weeks) were obtained from the Animal Core Facility of Nanjing Medical University. They were housed individually in cages under hygienic conditions and placed at a constant room temperature (23 ± 1°C) and humidity (30–40%) and maintained in a 12-h light/dark cycle room with … how is pergamon different in organizationWebCisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar … how is pericarditis treated